AlphaGenome 2 predicts how DNA variants act in specific human cell types

Key points

• Conditional model predicts DNA effects for one tissue, cell type or state at a time, trained on over 107 million cell profiles.
• On the TenK10K immune dataset, it identified 30% of causal variants versus 16% for the original AlphaGenome fine-tuned on single-cell data.
• Available now for non-commercial research via the AlphaGenome API; commercial access is in private preview.

Why it matters for marketers: Content and research teams can test variant effects in disease-relevant cell types, and can request community use-case spotlights by 30 November.